EMB-02
Induces PD-1 and LAG-3 Degradation; Blocks LAG-3 Binding to MHC-II and FGL-1
Western Blot analysis
PD-1 degradation was consistently observed with EMB-02 treatment
LAG-3 degradation observed 8 hours after EMB-02 treatment but not at the other evaluated timepoints
PD-1/LAG-3 degradation was only observed in FIT-Ig treatment group, demonstrating a possible synergistic effect
Blocks FGL-1 binding
EMB-02 blocks LAG-3 binding to canonical ligand MHC-II, as well as newfound ligand FGL-1, to stimulate the T cell immune response
