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Our Science
EpimAb's Proprietary Bispecific Platform : FIT-Ig®
Similar manufacturing convenience to monoclonal antibodies
Solubility comparable to monoclonal antibodies
Widely applicable to
multiple targets
Preserve the functions and properties of the monoclonal antibody
Tissue penetration
similar to monoclonal
antibodies
Production convenience
similar to monoclonal
antibodies
Pipeline
We have a robust and sustainable pipeline with 4 clinical stage assets (EMB-01, EMB-02 , EMB-06 and EMB-09) and more than 10 preclinical stage candidates. Our proprietary FIT-Ig® platform and other technical capabilities enable us to target three strategic oncology areas (tumor targeting, dual checkpoint inhibitors, immune cell engagers) and maintain our strong momentum to advance additional preclinical assets to the clinic.
EMB-02
Preclinical
Phase Ⅰ
Phase Ⅱ
Phase Ⅲ
EMB-01
EMB-01 is a novel bispecific antibody developed based on EpimAb’s proprietary FIT-Ig® platform to simultaneously target EGFR and cMet on tumor cells. It is being studied in Phase I/II clinical trials in NSCLC as well as several GI indications in the U.S. and China.
EGFR/cMET in NSCLC, Monotherapy
EMB-01
EMB-01 is a novel bispecific antibody developed based on EpimAb’s proprietary FIT-Ig® platform to simultaneously target EGFR and cMet on tumor cells. It is being studied in Phase I/II clinical trials in NSCLC as well as several GI indications in the U.S. and China.
EGFR/cMET in NSCLC, Combo with Tagrisso®
EMB-01
EMB-01 is a novel bispecific antibody developed based on EpimAb’s proprietary FIT-Ig® platform to simultaneously target EGFR and cMet on tumor cells. It is being studied in Phase I/II clinical trials in NSCLC as well as several GI indications in the U.S. and China.
EGFR/cMET in GI Cancers, Monotherapy
EMB-02
EMB-02 is a bispecific antibody targeting human programmed cell death protein 1 (PD-1) and lymphocyte-activation gene 3 (LAG-3) and is being evaluated in advanced solid tumors. This antibody is designed to target human PD-1 and LAG-3 concomitantly or independently and disrupt the immune suppression mediated by both pathways, thereby restoring T-cell effector function and enhancing anti-cancer activity. Currently, a global Phase I/II study is ongoing with sites opened in US, Australia, and China.
PD-1/LAG-3 in Solid Tumor
EMB-06
EMB-06 is a recombinant humanized bispecific antibody targeted against B cell maturation antigen (BCMA) and cluster of differentiation 3 (CD3). Upon binding to BCMA on tumor cell surface, EMB-06 can recruit and activate CD3 expressing T lymphocytes, thereby mediating the killing effect of T lymphocytes on tumor cells. Currently, a global Phase I/II study is enrolling patients in Australia and China.
BCMA/CD3 in Multiple Myeloma
EMB-09
EMB-09 is a novel bispecific antibody developed based on EpimAb’s proprietary FIT-Ig® platform to block PD-1/PD-L1 inhibitory signaling, and conditionally activate T effector cells by stimulating OX40 through PD-L1 dependent cross linking. EMB-09 showed superior immune cell activation in comparison with the mAb combinations. Its unique OX40 binding epitope could improve the therapeutic window, and silenced Fc effector function can avoid T effector cell depletion.
PD-L1/OX40 in Solid Tumor
EMB-07
EMB-07 is a T cell redirecting bispecific antibody by targeting a novel tumor associated antigen (ROR1) and cluster of differentiation 3 (CD3). EMB-07 is designed based on EpimAb’s proprietary bispecific antibody platform. Upon binding to TAA on the tumor cell surface, EMB-07 can recruit and activate CD3 expressing T lymphocytes, thereby promoting the cytotoxic effect of T lymphocytes. EMB-07 showed a promising preclinical efficacy and safety profile. IND submission is expected in 2022.
ROR1/CD3 in Solid Tumor & Hematologic Malignancies
News
2024-10-11
EpimAb Biotherapeutics Announces Upcoming Presentations at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC)
2024-09-04
EpimAb Biotherapeutics and Vignette Bio Announce Strategic Collaboration to Develop EMB-06, a BCMA×CD3 Bispecific Antibody
2024-03-06
EpimAb Biotherapeutics to Present Late-breaking Abstract on Preclinical Results of EMB-07 at the 2024 American Association for Cancer Research Annual Meeting
Who We Are
EpimAb Biotherapeutics is a clinical stage biopharmaceutical company with research and manufacturing facilities in Shanghai and Suzhou. With our unique and proprietary platform technology called FIT-Ig® (Fabs-In-Tandem Immunoglobulin) that is able to generate bispecific molecules with antibody-like properties, we are creating a pipeline of novel therapeutics focused around immuno-oncology and other disease areas with high unmet need.
EpimAb people
Platform Introduction
Management Team
Company Culture
Partnering Strategy
Contact
Shanghai
Adress
6th Floor, Building 2, Jinchuang Building, 702 Zhongke Road, Zhangjiang High-tech Park, Shanghai, 201204, China
Phone
+86-21-61951000
Email
contact@epimab.com
shanghai