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Our Science
EpimAb's Proprietary Bispecific Platform : FIT-Ig®
Similar manufacturing convenience to monoclonal antibodies
Solubility comparable to monoclonal antibodies
Widely applicable to
multiple targets
Preserve the functions and properties of the monoclonal antibody
Tissue penetration
similar to monoclonal
antibodies
Production convenience
similar to monoclonal
antibodies
Pipeline
We have a robust and sustainable pipeline with 4 clinical stage assets (EMB-01, EMB-02 , EMB-06 and EMB-09) and more than 10 preclinical stage candidates. Our proprietary FIT-Ig® platform and other technical capabilities enable us to target three strategic oncology areas (tumor targeting, dual checkpoint inhibitors, immune cell engagers) and maintain our strong momentum to advance additional preclinical assets to the clinic.
EMB-02
Preclinical
Phase Ⅰ
Phase Ⅱ
Phase Ⅲ
EMB-01
EMB-01 is a novel bispecific antibody developed based on EpimAb’sproprietary FIT-Ig® platform to simultaneously target EGFR and cMeton tumor cells. It is being studied in Phase I/II clinical trials in several GI indications in the U.S. and China.
Gastrointestinal Cancers, mono drug
EMB-06
EMB-06 is a recombinant humanized bispecific antibody targeted against B cell maturation antigen (BCMA) and cluster of differentiation 3 (CD3). Upon binding to BCMA on tumor cell surface, EMB-06 can recruit and activate CD3 expressing T lymphocytes, thereby mediating the killing effect of T lymphocytes on tumor cells. Currently, a global Phase I/II study is enrolling patients in Australia and China.
BCMA/CD3 Multiple myeloma/Autoimmune disease
EMB-06
EMB-06 is a recombinant humanized bispecific antibody targeted against B cell maturation antigen (BCMA) and cluster of differentiation 3 (CD3). Upon binding to BCMA on tumor cell surface, EMB-06 can recruit and activate CD3 expressing T lymphocytes, thereby mediating the killing effect of T lymphocytes on tumor cells. Currently, a global Phase I/II study is enrolling patients in Australia and China.
BCMA/CD3 All indication
EMB-07
EMB-07 is a T cell redirecting bispecific antibody by targeting a novel tumor associated antigen (ROR1) and cluster of differentiation 3 (CD3). EMB-07 is designed based on EpimAb’sproprietary bispecific antibody platform. Upon binding to TAA on the tumor cell surface, EMB-07 can recruit and activate CD3 expressing T lymphocytes, thereby promoting the cytotoxic effect of T lymphocytes. EMB-07 showed a promising preclinical efficacy and safety profile. EMB-07 is undergoing phase I trials.
ROR1/CD3 Solid tumors and hematologic malignancies
EMB-09
EMB-09 is a novel bispecific antibody developed based on EpimAb’s proprietary FIT-Ig® platform to block PD-1/PD-L1 inhibitory signaling, and conditionally activate T effector cells by stimulating OX40 through PD-L1 dependent cross linking. EMB-09 showed superior immune cell activation in comparison with the mAb combinations. Its unique OX40 binding epitope could improve the therapeutic window, and silenced Fc effector function can avoid T effector cell depletion.
PD-L1/OX40 in Solid Tumor
News
2024-12-16
Candid Therapeutics and EpimAb Biotherapeutics Enter Into Research Collaboration to Discover and Develop Novel T-Cell Engagers for Autoimmune Indications
2024-12-06
EpimAb Biotherapeutics Announces Oral Presentation for EMB-06 (CND106) First-in-human (FIH) Phase I Study in Multiple Myeloma at the American Society of Hematology (ASH) 2024 Annual Meeting
2024-10-11
EpimAb Biotherapeutics Announces Upcoming Presentations at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC)
Who We Are
EpimAb Biotherapeutics is a clinical stage biopharmaceutical company with research and manufacturing facilities in Shanghai and Suzhou. With our unique and proprietary platform technology called FIT-Ig® (Fabs-In-Tandem Immunoglobulin) that is able to generate bispecific molecules with antibody-like properties, we are creating a pipeline of novel therapeutics focused around immuno-oncology and other disease areas with high unmet need.
EpimAb people
Platform Introduction
Management Team
Company Culture
Partnering Strategy
Contact
Shanghai
Adress
6th Floor, Building 2, Jinchuang Building, 702 Zhongke Road, Zhangjiang High-tech Park, Shanghai, 201204, China
Phone
+86-21-61951000
Email
contact@epimab.com
shanghai