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技术平台
岸迈生物具有自主知识产权的双抗技术平台
广泛地适用于多种靶点
与单抗相似的生产便利
性和工艺放大能力
与单抗相似的药代动力学
特性以及免疫原性
保留单抗的结合功能和
亲和力
与单抗相当的可溶性及
稳定性
基于稳定细胞株能快速
进行产业化
产品管线
EpimAb拥有强大和可持续的产品管线，目前有4个临床项目 ( EMB-01、EMB-02、EMB-06和EMB-09 ) 以及10多个临床前候选药物。专有的双特异性平台FIT-Ig®使EpimAb能够精准覆盖三个战略肿瘤学领域 ( 肿瘤靶向、双免疫检查点、免疫细胞导向 )，并保持推动更多临床前项目进入临床的强劲势头。
EMB-02
Preclinical
Phase Ⅰ
Phase Ⅱ
Phase Ⅲ
EMB-01
EMB-01 is a novel bispecific antibody developed based on EpimAb’s proprietary FIT-Ig® platform to simultaneously target EGFR and cMet on tumor cells. It is being studied in Phase I/II clinical trials in NSCLC as well as several GI indications in the U.S. and China.
Gastrointestinal Cancers, mono drug
EMB-06
EMB-06 is a recombinant humanized bispecific antibody targeted against B cell maturation antigen (BCMA) and cluster of differentiation 3 (CD3). Upon binding to BCMA on tumor cell surface, EMB-06 can recruit and activate CD3 expressing T lymphocytes, thereby mediating the killing effect of T lymphocytes on tumor cells. Currently, a global Phase I/II study is enrolling patients in Australia and China.
BCMA/CD3 All indication
EMB-06
EMB-06 is a recombinant humanized bispecific antibody targeted against B cell maturation antigen (BCMA) and cluster of differentiation 3 (CD3). Upon binding to BCMA on tumor cell surface, EMB-06 can recruit and activate CD3 expressing T lymphocytes, thereby mediating the killing effect of T lymphocytes on tumor cells. Currently, a global Phase I/II study is enrolling patients in Australia and China.
BCMA/CD3 Multiple myeloma/Autoimmune disease
EMB-07
EMB-07 is a T cell redirecting bispecific antibody by targeting a novel tumor associated antigen (ROR1) and cluster of differentiation 3 (CD3). EMB-07 is designed based on EpimAb’s proprietary bispecific antibody platform. Upon binding to TAA on the tumor cell surface, EMB-07 can recruit and activate CD3 expressing T lymphocytes, thereby promoting the cytotoxic effect of T lymphocytes. EMB-07 showed a promising preclinical efficacy and safety profile. IND submission is expected in 2022.
ROR1/CD3 Solid tumors and hematologic malignancies
EMB-09
EMB-09 is a novel bispecific antibody developed based on EpimAb’s proprietary FIT-Ig® platform to block PD-1/PD-L1 inhibitory signaling, and conditionally activate T effector cells by stimulating OX40 through PD-L1 dependent cross linking. EMB-09 showed superior immune cell activation in comparison with the mAb combinations. Its unique OX40 binding epitope could improve the therapeutic window, and silenced Fc effector function can avoid T effector cell depletion.
PD-L1/OX40 in Solid Tumor
News
2024-12-16
Candid Therapeutics and EpimAb Biotherapeutics Enter Into Research Collaboration to Discover and Develop Novel T-Cell Engagers for Autoimmune Indications
2024-12-06
EpimAb Biotherapeutics Announces Oral Presentation for EMB-06 (CND106) First-in-human (FIH) Phase I Study in Multiple Myeloma at the American Society of Hematology (ASH) 2024 Annual Meeting
2024-10-11
EpimAb Biotherapeutics Announces Upcoming Presentations at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC)
关于岸迈
岸迈生物是一家创新型国际化生物技术企业，在上海和苏州分别设有研发中心和GMP生产基地，专注于利用自主知识产权的双特异性抗体技术平台FIT-Ig®进行创新生物药的研究和开发。基于FIT-Ig®平台技术，岸迈生物正在针对免疫肿瘤和其他临床需求高的领域进行双特异性抗体系列原创产品的开发。岸迈生物同时也在通过全球范围内的技术授权、合作开发等多种形式实现平台的战略发展和产品多元化布局。
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中国上海市张江高科技园区中科路702号金创大厦2栋6楼
邮编：201204
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+86-21-61951000
邮箱
contact@epimab.com
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